{"id":141,"date":"2020-08-14T13:02:53","date_gmt":"2020-08-14T11:02:53","guid":{"rendered":"http:\/\/www.hbimed.com\/wp-enfold-aug2020\/?page_id=141"},"modified":"2020-08-14T13:02:53","modified_gmt":"2020-08-14T11:02:53","slug":"why-biomarker","status":"publish","type":"page","link":"https:\/\/hbimed.com\/en\/wozu-biomarker\/","title":{"rendered":"What are biomarkers for"},"content":{"rendered":"<div id='av_section_1'  class='avia-section av-1m486-c4ba37123efc5011fae03206ec432ee7 main_color avia-section-default avia-no-border-styling  avia-builder-el-0  el_before_av_section  avia-builder-el-first  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-141'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-s82i-5e70d99c8233c51b6166d65407b030cd\">\n.flex_column.av-s82i-5e70d99c8233c51b6166d65407b030cd{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-s82i-5e70d99c8233c51b6166d65407b030cd av_one_full  avia-builder-el-1  avia-builder-el-no-sibling  first flex_column_div av-zero-column-padding'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-8696aa76e2cef520f42dca85f4c138f2\">\n#top .av-special-heading.av-av_heading-8696aa76e2cef520f42dca85f4c138f2{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-av_heading-8696aa76e2cef520f42dca85f4c138f2 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-8696aa76e2cef520f42dca85f4c138f2 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-8696aa76e2cef520f42dca85f4c138f2 av-special-heading-h1 blockquote modern-quote  avia-builder-el-2  el_before_av_textblock  avia-builder-el-first'><h1 class='av-special-heading-tag'  itemprop=\"headline\"  >Biomarkers are used for a variety of purposes in medicine and research. They can help diagnose diseases, monitor their progression, predict treatment response, and even assess a person's risk of developing certain conditions.<\/h1><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-kdoek3vo-272befba42fc51414855ade34c25da1f'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Psychologists rely on psychometrics to assess personality, psychopathology, motivation, and learning disabilities. However, despite built-in lie scales, split-half designs, and a variety of other statistical manipulations, psychometric measurements still consist of behavioral data that is judged and reported by the individual themselves or by others.<\/p>\n<p>The fifth, revised edition of\u201e<strong>The Diagnostic and Statistical Manual of Mental Disorders (DSM-5)<\/strong>\u00a0was initially aimed at classifying mental disorders based on biological markers. The reserved reaction from the field and currently too many uncertainties prompted the developers to postpone the biomarker approach for the 6th revision. The new approach assumes that psychiatric diagnoses are not made solely on observable behavior, but also on knowledge of which brain system is impaired. The biomarker approach is almost certain to prevail because it creates objectivity and traceability. HBImed, like thousands of other researchers, has already conducted intensive research in this field and identified parameters of quantitative electroencephalography (<strong>QEEG<\/strong>) and components of evoked potentials (<strong>Event-Related Potentials \u2013 ERPs<\/strong>) can be defined as discrimination-capable biomarkers for various mental disorders.<\/p>\n<p>Recent research shows that certain dysfunctions, such as ADHD, schizophrenia, obsessive-compulsive disorder, depression, specific learning disorders, and others, are associated with specific patterns of spontaneous and evoked electrical potentials recorded via multiple surface electrodes on the scalp, and that these spontaneous and especially evoked electrical potentials represent reliable markers of brain function and dysfunction.<\/p>\n<p>Measurements of spontaneous and evoked electrical potentials can be compared with data from a normative database (e.g., the Human Brain Index Reference Database (HBIRD)). By comparing the data using parametric statistical methods, differences of patients from their corresponding age-adjusted reference group can be calculated. This computer analysis then serves as a valuable tool for diagnosis, therapy planning, and thus enabling personalized medicine.<\/p>\n<p>For more information on QEEG, with a special focus on ADHD, here are two brief introductions:<\/p>\n<ul>\n<li>Andreas M\u00fcller:\u00a0<a href=\"https:\/\/hbi-reports.com\/forschung\/\" rel=\"noopener\">ADHD Biomarker for Diagnosis and Treatment<\/a><\/li>\n<li>Prof. Juri Kropotov:\u00a0<a title=\"To the menu item Research\" href=\"https:\/\/hbi-reports.com\/de\/forschung\/\">New tools for the diagnosis and modulation of brain dysfunction.<\/a><\/li>\n<\/ul>\n<p>Do you have questions about ERP-based biomarkers or the HBI database?\u00a0<a title=\"To the Contact menu item\" href=\"https:\/\/hbi-reports.com\/de\/service\/kontakt\/\">Then simply contact us!<\/a><\/p>\n<\/div><\/section><\/p><\/div><\/div><\/div><\/main><!-- close content main element --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-&apos;av-jpr4h52r&apos;-ee4d9a51b9f5f0fe2e7ef1fa03246151\">\n.avia-section.&apos;av-jpr4h52r&apos;-ee4d9a51b9f5f0fe2e7ef1fa03246151{\nbackground-color:&apos;&apos;;\nbackground-image:unset;\n}\n.avia-section.&apos;av-jpr4h52r&apos;-ee4d9a51b9f5f0fe2e7ef1fa03246151 .av-section-color-overlay{\nopacity:&apos;0.5&apos;;\nbackground-color:&apos;#ffffff&apos;;\nbackground-image:url(&apos;&apos;);\nbackground-repeat:repeat;\n}\n<\/style>\n<div id='av_section_2' aria-label='&amp;apos;&amp;apos;' class='avia-section &apos;av-jpr4h52r&apos;-ee4d9a51b9f5f0fe2e7ef1fa03246151 &apos;main_color&apos; 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